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KMID : 1161420200230091014
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Journal of Medicinal Food
2020 Volume.23 No. 9 p.1014 ~ p.1018
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Black Tea Exhibits a Dose-Dependent Response in Saos-2 Cell Mineralization
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Cleverdon Riley E.
McAlpine Michael D.
Ward Wendy E.
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Abstract
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Higher bone mineral density (BMD) is often associated with greater consumption of black tea (BT). However, the dose?response of BT on mineralization in an osteoblast cell model has not yet been studied. The study objective was to determine the dose-dependent response of BT in Saos-2 cells and investigate changes to several proteins involved in the mineralization process. Mineralization was induced in the presence of BT at concentrations that represent levels likely achieved through daily consumption (0.1, 0.5, 0.75, 1?μg gallic acid equivalents [GAE]/mL) or through supplementation (2, 5, or 10?μg GAE/mL). BT exerted a positive dose?response on bone mineralization, peaking at 1?μg GAE/mL of BT (P?
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KEYWORD
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antioxidant, bone, cell culture, nutrition, osteoblast, tea
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